@prefix this: . @prefix sub: . @prefix schema: . @prefix np: . @prefix dct: . @prefix pav: . @prefix nt: . @prefix npx: . @prefix xsd: . @prefix rdfs: . @prefix prov: . @prefix wd: . @prefix foaf: . sub:Head { this: a np:Nanopublication; np:hasAssertion sub:assertion; np:hasProvenance sub:provenance; np:hasPublicationInfo sub:pubinfo . } sub:assertion { sub:glycan-protein-motifs a wd:Q604733; dct:description "

Motivation: We have previously designed and implemented a tree-based ontology to represent glycan structures with the aim of searching these structures with a glyco-driven syntax. This resulted in creating the GlySTreeM knowledge-base as a linchpin of the structural matching procedure and we now introduce a query language, called GlycoQL, for the actual implementation of a glycan structure search.

Results: The methodology is described and illustrated with a use-case focused on Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) spike protein glycosylation. We show how to enhance site annotation with federated queries involving UniProt and GlyConnect, our glycoprotein database.

Availability and implementation: https://glyconnect.expasy.org/glycoql/

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