@prefix this: <https://w3id.org/np/RAQSO62eVN8MzmzAvJ2YmvoodGAhQZNIynKXyW1fkYrHw> .
@prefix sub: <https://w3id.org/np/RAQSO62eVN8MzmzAvJ2YmvoodGAhQZNIynKXyW1fkYrHw/> .
@prefix schema: <https://schema.org/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix nt: <https://w3id.org/np/o/ntemplate/> .
@prefix npx: <http://purl.org/nanopub/x/> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix orcid: <https://orcid.org/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix obo: <http://purl.obolibrary.org/obo/> .
@prefix foaf: <http://xmlns.com/foaf/0.1/> .

sub:Head {
  this: a np:Nanopublication;
    np:hasAssertion sub:assertion;
    np:hasProvenance sub:provenance;
    np:hasPublicationInfo sub:pubinfo .
}

sub:assertion {
  sub:vana-dissemination a obo:OBI_0000066, obo:OBI_0003693, schema:MedicalObservationalStudy;
    dct:description "Retrospective genomic-epidemiology study of 309 vancomycin-resistant Enterococcus faecium (VRE) isolates collected in 32 Dutch hospitals (2012-2015), combining short-read and long-read whole-genome sequencing to determine whether vanA-type vancomycin resistance disseminated clonally or horizontally via plasmids and Tn1546 transposition. The study found that resistance spread through both modes, with plasmid-mediated horizontal transfer playing a substantial role.";
    dct:isPartOf <https://w3id.org/spaces/zonmw/antibiotica-resistentie-abr/541003005>;
    rdfs:label "Mode and dynamics of vanA-type vancomycin resistance dissemination in Dutch hospitals";
    rdfs:seeAlso <https://doi.org/10.1186/s13073-020-00825-3>;
    prov:wasAssociatedWith orcid:0000-0002-4445-2442, orcid:0000-0003-1894-7545 .
}

sub:provenance {
  sub:assertion prov:wasDerivedFrom <https://doi.org/10.1186/s13073-020-00825-3>, <https://projecten.zonmw.nl/nl/project/vre-crossword-horizontal-or-vertical-transmission-vancomycin-resistant-enterococcus-faecium> .
}

sub:pubinfo {
  obo:OBI_0000066 rdfs:label "study" .
  
  obo:OBI_0003693 rdfs:label "observational investigation" .
  
  orcid:0000-0002-1267-0234 foaf:name "Tobias Kuhn" .
  
  orcid:0000-0002-4445-2442 foaf:name "Sergio Arredondo-Alonso" .
  
  orcid:0000-0003-1894-7545 foaf:name "Anita C. Schürch" .
  
  schema:MedicalObservationalStudy rdfs:label "medical observational study" .
  
  this: dct:created "2026-08-14T06:30:00Z"^^xsd:dateTime;
    dct:creator orcid:0000-0002-1267-0234;
    dct:license <https://creativecommons.org/publicdomain/zero/1.0/>;
    npx:hasNanopubType obo:OBI_0000066;
    npx:introduces sub:vana-dissemination;
    npx:supersedes <https://w3id.org/np/RAvNOeFapxx4b5XnTV0pJ3bO705nMOJSBT6nnGKkUvVao>;
    rdfs:label "Study: Mode and dynamics of vanA-type vancomycin resistance dissemination in Dutch hospitals";
    nt:wasCreatedFromProvenanceTemplate <https://w3id.org/np/RAmRxSMXuHZWtDXqTXqTK_aM1KBPauATJg4_KqixamLiE>;
    nt:wasCreatedFromPubinfoTemplate <https://w3id.org/np/RACJ58Gvyn91LqCKIO9zu1eijDQIeEff28iyDrJgjSJF8>,
      <https://w3id.org/np/RAoTD7udB2KtUuOuAe74tJi1t3VzK0DyWS7rYVAq1GRvw>, <https://w3id.org/np/RAukAcWHRDlkqxk7H2XNSegc1WnHI569INvNr-xdptDGI>;
    nt:wasCreatedFromTemplate <https://w3id.org/np/RAWaGj1HOf1_9D-zgvejQ3GCcCIFu4qBArSYKguPU0r5Y> .
  
  sub:sig npx:hasAlgorithm "RSA";
    npx:hasPublicKey "MIGfMA0GCSqGSIb3DQEBAQUAA4GNADCBiQKBgQCwUtewGCpT5vIfXYE1bmf/Uqu1ojqnWdYxv+ySO80ul8Gu7m8KoyPAwuvaPj0lvPtHrg000qMmkxzKhYknEjq8v7EerxZNYp5B3/3+5ZpuWOYAs78UnQVjbHSmDdmryr4D4VvvNIiUmd0yxci47dTFUj4DvfHnGd6hVe5+goqdcwIDAQAB";
    npx:hasSignature "UMCfwD6FBDV6UrLhaxOcBO4j2NFsIX2jE8YP/B/Pmo4AnCcad65fnbGsb5YlJvzN+xEtRCXWMYx12orNM/ikSA16flfUhpQ6DM7bBdWhZSEG1uNr2+Z2ZIfM2EPjqxBVb2yRrjeJuKD9Wh1SAgQnOD99pVqZFZ/CmAHOycy21mQ=";
    npx:hasSignatureTarget this:;
    npx:signedBy orcid:0000-0002-1267-0234 .
  
  <https://w3id.org/spaces/zonmw/antibiotica-resistentie-abr/541003005> nt:hasLabelFromApi
      "VRE-crossword, horizontal or vertical? Transmission of vancomycin-resistant Enterococcus faecium in Dutch hospitals" .
}